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KMID : 1189419990120010047
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
1999 Volume.12 No. 1 p.47 ~ p.78
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Experimental study on the Anti-inflammatory and wound healing effect of Hoichunyanggyuksan and Yongseksa.
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Kang Shung-Won
Roh Seok-Seon
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Abstract
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Hoichunyonggyuksan(HCYGS) and Yongseksan(YSS) are important prescriptions that have been used in oriental medicine for stomatitis and wound healing. The study was done to evaluate the inhibitory effects of cytotoxicity, formation of superoxide on the macrophage and neutrophil, prostaglandins(PGE_2), interleukins(IL-1β), collagenase activity and synthesis of collagen and DNA. The results were obtained as fo1lows: 1. HCYGS and YSS were not showed the proliferation difference of human fibroblast and monocyte in all concentrations to be experimented and in result, it was concluded that they have no cytotoxicity. 2. YSS inhibited the formation of superoxide to 48% at the concentration of 0.001% in the mouse monocyte. 3. HCYGS inhibited the formation of superoxide to 13% at the concentration of 0.001% as compared with control in the human monocyte. 4. HCYGS and YSS inhibited the formation of superoxide to 25% and 35% respectively at the concentration of 0.0001% and HCYGS ;showed ;38% inhihitory rate on the formation of superoxide at concentration of 0.001% in the human neutrophil. 5. The concentration of inhibiting the production of prostaglandins(PGE_2) to 11% in the human monocyte stimulated with E. coli were 0.01% of HCYGS. 6. The concentration of inhibiting the production of interleukins(IL-lβ) to 43% and 39% in the human monocyte stimulated with E. coli were 0.01% of HCYGS and YSS. 7. HCYGS and YSS didn't influence on collagen synthesis and total protein in fibroblasts. 8. HCYGS and YSS inhibited the collagenase activity to 22% and 19 % at 0.1%, 45% and 56% at 0.2%, 57% and 52% at 0.5% respectively, but YSS exerted the inhibitory effect on collagenase activity to 27% at the lower concentration of 0.01%. 9. HCYGS and YSS didn't show the faster recovary than control group hut exerted the consistant effect on the anti-inflammations and the formation of granulation tissue.
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KEYWORD
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